NICOTINIC ACID IN BREWING MATERIALS

Experience with Nicotinic Acid

Nicotinic Acid Metabolism

Previous reports from this laboratory have described the isolation of 6-hydroxynicotinic acid and 6-0x0-1 ,4,5,6-tetrahydronicotinic acid from the reaction media of a clostridial species grown on nicotinic acid (1). Bn enzyme that catalyzes the reversible oxidation of nicotinic acid to HNA’ has been purified from extracts of this microorganism (2). Since fortified crude extract of this Clostrid...

Nicotinic acid metabolism. II. The isolation and characterization of intermediates in the fermentation of nicotinic acid.

6-Hydroxynicotinic acid was demonstrated to be the first intermediate in the degradation of nicotinic acid by a clostridium. In the presence of pyruvate, other intermediates accumulated; two of these were identified, one as 1,4,5,6tetrahydro-6-oxonicotinic acid, and the other as a!-methyleneglutaric acid. The pathways for nicotinic acid degradation may be considered as involving successive oxid...

Tredaptive, INN-nicotinic acid/laropiprant

Bacterial Fermentation of Nicotinic Acid

The ability of certain bacterial species to oxidize nicotinic acid was first reported by Allison (1) who used suspensions of bacteria isolated by Dubos and Miller (2). Koser and Baird (3) later isolated strains of Pseudomonas jluorescens which grew on a synthetic medium in which nicotinic acid was the sole carbon source. These strains did not attack isonicotinic acid, picolinic acid, or pyridin...